Email is sent out from Application using an email address application@sample.com. This application will send daily more than 500 emails to internal/External recipients.

Often we are not unable to update/remove  leavers or invalid external email address in this application, therefore a lot of "undeliverable" email messages are generated in response to outbound email.  These replies are sent back to application@sample.com , it tries to process them and creates large amounts of unnecessary data.

Is there any option place against this mailbox so any "undeliverable" response is dropped, i.e. do not reply back to the senders mailbox ?.

Note : I do not want  to create outlook rule to delete undelivered mail.

Thanks,

Sounds like what you want to accomplish should be doable with a transport rule.  Take a look at the documentation below. 

https://technet.microsoft.com/en-us/library/dd351127(v=exchg.150).aspx

Hi Amjath,

Such a interesting query .Hope you are doing good.

Based on my knowledge , the possible and advisable way to overcome this issue is to have the outlook rule on that particular mailbox to drop the NDR messages.

However we can try the below mentioned steps.

1.I hope the mentioned mailbox is only used to send the emails .On such case just try to have the receive size of the mailbox to 0 kB and check the results.If we set like that then there wouldn't be chance to receive the NDR as well the normal emails.

2.I am not sure , just try to have the Microsoft exchange recipient address and postmaster address on the reject messages option on that application mailbox.

Note : First two options needs to be tested first on the test environment and then implement it on production environment.Because on the first step we are prohibiting the receive quota and on the second step we are rejecting the NDR messages .That means again an NDR message will get generated from the Microsoft exchange recipient address to the same Microsoft exchange recipient address or else to the the post master address .But those messages will be discarded if we don't have the mailbox for the MicrosoftExchangeRecipientReplyRecipient and ExternalPostmasterAddress.

Based on my knowledge transport rules on the hub transport servers will not work on the system messages like NDR.

Reference link : 

https://technet.microsoft.com/en-us/library/bb124703%28v=exchg.141%29.aspx

Hi,

In addition to the above suggestion, you can use the following cmdlet to disable NDR.

Set-RemoteDomain Contoso -NDREnabled $false

Note that this cmdlet will disable all the non-delivery reports to the remote domain.

Hope this can be helpful to you.

Best regards,